Association of amyloid and cardiovascular risk with cognition: Findings from KBASE
Vascular risk significantly affects cognition in amyloid-negative older Koreans. Amyloid-negative CN older adults with high vascular risk had lower baseline cognition. Amyloid pathology drives cognitive decline in CN and MCI, regardless of vascular risk. The study underscores the impact of vascular health on the AD disease spectrum.
Authors
- Evgeny J. Chumin (ORCID: https://orcid.org/0000-0001-6696-6105)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Michael K. Lee (ORCID: https://orcid.org/0000-0001-5865-9682)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Tamina Park
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Koung Mi Kang (ORCID: https://orcid.org/0000-0001-9643-2008)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Desarae A. Dempsey (ORCID: https://orcid.org/0000-0003-4681-0108)
- Connie Nakano
- Soumilee Chaudhuri (ORCID: https://orcid.org/0000-0002-8488-6114)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Phoebe Scollard
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Sha Cao
- Kwangsik Nho
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Hannah Craft
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee
- Yoon‐Keun Kim (ORCID: https://orcid.org/0000-0001-7610-7654)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Yen‐Ning Huang
Institutions
- Boston University (US)
- Seoul National University (KR)
- University of Washington (US)
- Harborview Medical Center (US)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- VA Puget Sound Health Care System (US)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1002/alz.14290
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Alzheimer's Disease Neuroimaging Initiative
- Seoul National University
- National Institutes of Health
- National Institute on Aging