Vitamin D 1,25-Dihydroxyvitamin D<sub>3</sub> reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization
Supplementation with 1,25(OH)<sub>2</sub>D<sub>3</sub> improved hepatic steatosis and lipid metabolism in NAFLD, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the VDR-PPARγ pathway. The involvement of 1,25(OH)<sub>2</sub>D<sub>3</sub> in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes.
Authors
- Xianwen Dong (ORCID: https://orcid.org/0000-0002-8977-3485)
- Qiubo Zhang (ORCID: https://orcid.org/0000-0002-1649-9876)
- Huiwei Liu (ORCID: https://orcid.org/0000-0002-8882-0059)
- Wenjing Luo (ORCID: https://orcid.org/0000-0002-6847-0629)
- Wenying Guo (ORCID: https://orcid.org/0009-0002-0788-5932)
- Hua Ye (ORCID: https://orcid.org/0000-0001-9930-6023)
- Qiong Zhao (ORCID: https://orcid.org/0000-0003-2814-1641)
- Feng Xu
Institutions
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.4251/wjgo.v16.i12.4685
- Citations
- 8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.92