Brain drug delivery from the nasal olfactory region is enhanced using lauroylcholine chloride: An estimation using in vivo PET imaging
LCC effectively enhances the domperidone delivery from the rat olfactory region to the brain, probably not via a circulating blood. The combination of permeation enhancers and olfactory region-selective drug administration could be effective for N2B drug delivery.
Authors
- Keita Sasaki (ORCID: https://orcid.org/0009-0005-5100-3863)
- Chie Suzuki (ORCID: https://orcid.org/0000-0002-7997-1955)
- Shota Fukakusa
- Yoh Sonoda
- Yasuhiro Magata (ORCID: https://orcid.org/0000-0001-5924-8500)
- Shunji Haruta
- Yasuyo Hatano (ORCID: https://orcid.org/0000-0002-7914-8846)
Institutions
- Hamamatsu University School of Medicine (JP)
- Shin Nippon Biomedical Laboratories (Japan) (JP)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.nucmedbio.2024.108968
- Citations
- 7
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 1.46