Improved 2D hydride detection for NMR-chemosensing via p‐H2 Hyperpolarization

• Non hydrogenative PHIP allows NMR detection of dilute analytes in complex mixtures. • 2D correlation experiment allows fast acquisition of high-resolution spectra • Homodecoupling affords enhanced signals and lower spectral crowding 2D NMR zero-quantum spectroscopy offers a robust and convenient way to resolve hydride resonances in non-hydrogenative ParaHydrogen Induced Polarization experiments. This approach has been recently applied to the detection and quantification of dilute components in biofluids and natural extracts. For certain classes of analytes, however, modulation of the zero-quantum coherence occurs at several kiloHertz frequency, which determines long measurement times for attaining the desired resolution in the indirect dimension. Here, we propose an alternative 2D approach to measure high-resolution NMR spectra that affords enhanced sensitivity and reduced experimental time for optimal sample throughput.