Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era
Our study highlights meningitis as a significant contributor to under-5 mortality in low-middle-income countries. The prominent role of K. pneumoniae and A. baumannii, particularly in healthcare settings and specific regions, highlights the need for better infection control, targeted interventions, and more effective treatment strategies.
Authors
- Soter Ameh (ORCID: https://orcid.org/0000-0002-8449-6423)
- Marcelino Garrine (ORCID: https://orcid.org/0000-0002-8619-8761)
- Dianna M. Blau (ORCID: https://orcid.org/0000-0002-1253-198X)
- J. Anthony G. Scott (ORCID: https://orcid.org/0000-0001-7533-5006)
- Lemma Demissie Regassa (ORCID: https://orcid.org/0000-0002-5461-5348)
- Karen L. Kotloff (ORCID: https://orcid.org/0000-0003-1808-6431)
- Inácio Mandomando (ORCID: https://orcid.org/0000-0002-1078-2187)
- Lola Madrid (ORCID: https://orcid.org/0000-0003-4034-6033)
- Brigitte Gaume
- Victor Akelo (ORCID: https://orcid.org/0000-0001-7518-2855)
- Clayton Onyango (ORCID: https://orcid.org/0000-0003-3418-5042)
- Sana Mahtab (ORCID: https://orcid.org/0000-0002-2606-6951)
- Vicky L. Baillie (ORCID: https://orcid.org/0000-0003-1327-9090)
- Dickens Onyango (ORCID: https://orcid.org/0000-0002-1634-0531)
- Zachary J. Madewell (ORCID: https://orcid.org/0000-0002-5667-9660)
- Erick Kaluma
- Portia Mutevedzi (ORCID: https://orcid.org/0000-0001-6354-0803)
- Samba O. Sow (ORCID: https://orcid.org/0000-0002-6335-5066)
- Shams El Arifeen (ORCID: https://orcid.org/0000-0002-5372-5932)
- Sara Ajanovic (ORCID: https://orcid.org/0000-0002-6137-8619)
- Milagritos D. Tapia (ORCID: https://orcid.org/0000-0002-6476-3934)
- Ikechukwu U. Ogbuanu (ORCID: https://orcid.org/0000-0002-0670-6026)
- Emily S. Gurley (ORCID: https://orcid.org/0000-0002-8648-9403)
- Mulu Berihun
- Cynthia G. Whitney (ORCID: https://orcid.org/0000-0002-1056-3216)
- Shabir Ahmed Madhi (ORCID: https://orcid.org/0000-0002-7629-0636)
- Nega Assefa (ORCID: https://orcid.org/0000-0003-0341-2329)
- Rosauro Varo (ORCID: https://orcid.org/0000-0003-4282-5572)
- Elísio Xerinda (ORCID: https://orcid.org/0000-0003-0715-2034)
- Quique Bassat (ORCID: https://orcid.org/0000-0003-0875-7596)
- Okokon Ita (ORCID: https://orcid.org/0000-0003-1149-3130)
- Muntasir Alam (ORCID: https://orcid.org/0000-0001-8752-4592)
- Kitiezo Aggrey Igunza (ORCID: https://orcid.org/0000-0002-5841-5431)
- Ziyaad Dangor (ORCID: https://orcid.org/0000-0003-4089-147X)
- Jennifer R. Verani (ORCID: https://orcid.org/0000-0001-5267-1883)
- Mahbubur Rahman (ORCID: https://orcid.org/0000-0001-8577-8281)
- Mohammad Zahid Hossain (ORCID: https://orcid.org/0000-0003-0511-4085)
- Joseph Bangura
- Sanjay G. Lala (ORCID: https://orcid.org/0000-0001-9964-513X)
Institutions
- South African Medical Research Council (ZA)
- University of Maryland, Baltimore (US)
- Centers for Disease Control and Prevention (US)
- Johns Hopkins University (US)
- Emory University (US)
- Haramaya University (ET)
- University of Sierra Leone (SL)
- National Center for Immunization and Respiratory Diseases (US)
- University of the Witwatersrand (ZA)
- International Centre for Diarrhoeal Disease Research (BD)
- Kenya Medical Research Institute (KE)
- University of Calabar (NG)
- Centre Pour le Développement des Vaccins-Mali (ML)
- London School of Hygiene & Tropical Medicine (GB)
- Departament de Salut (ES)
- Ministry of Health and Sanitation (SL)
- Manhiça Health Research Centre (MZ)
- Instituto Nacional de Saúde (MZ)
- Centers for Disease Control and Prevention (KE)
- Sierra Leone Urban Research Centre (SL)
- Agencia de Salud Pública de Barcelona (ES)
- Sierra Leone Agricultural Research Institute (SL)
- South African Institute for Medical Research (ZA)
- Great Lakes University of Kisumu (KE)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1016/j.jinf.2024.106341
- Citations
- 8
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- World Health Organization
- Emory University
- Centres de Recerca de Catalunya
- Generalitat de Catalunya
- Agencia Española de Cooperación Internacional para el Desarrollo
- Agencia Estatal de Investigación