Intracellular dark spots are associated with endothelial cell loss after Descemet’s stripping automated endothelial keratoplasty
Intracellular dark endothelial spots (IDESs) on specular microscopy developed in 78/122 patients (63.9%) after Descemet stripping automated endothelial keratoplasty (DSAEK). Endothelial cell density (ECD) after DSAEK was significantly smaller in eyes with IDES when compared with those without at all time points (p<0.001) despite no significant difference in graft ECD (p=0.43), resulting in an increased rate of endothelial failure (p=0.044). The presence of glaucoma (OR=2.22, p=0.027), iris damage (OR=2.85, p=0.004) and non-Fuchs status (OR=2.37, p=0.018) were identified as risk factors for IDES development. Preoperative total protein level in aqueous humour was significantly higher in eye with endothelial failure than those without (p=0.0057).
Authors
- Toshimitsu Kanda
- Takefumi Yamaguchi (ORCID: https://orcid.org/0000-0002-2546-2813)
- Kazunari Higa (ORCID: https://orcid.org/0000-0002-2015-3480)
- Osama Mohamed Ibrahim (ORCID: https://orcid.org/0000-0002-2868-039X)
- Yukari Yagi-Yaguchi (ORCID: https://orcid.org/0000-0002-7980-7741)
- Takahiko Hayashi (ORCID: https://orcid.org/0000-0001-8704-680X)
- Jun Shimazaki (ORCID: https://orcid.org/0000-0002-0435-3095)
- Daisuke Tomida (ORCID: https://orcid.org/0000-0002-6361-3600)
- Hirotsugu Kasamatsu
- Yoshinori Oie
- Yurina Mori-Ogiwara
Institutions
- Nihon University (JP)
- Tokyo Dental College Ichikawa General Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1136/bjo-2024-325702
- Citations
- 4
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science