Lipid-lowering drug and complement factor H genotyping–personalized treatment strategy for age-related macular degeneration
We investigated whether the effect of lipid-lowering drugs (LLDs) on age-related macular degeneration (AMD) differs according to the main complement genetic variants in Singapore Epidemiology of Eye Diseases (SEED) (<i>n</i> = 5,579) and UK Biobank studies (<i>n</i> = 445,727). The effect of LLD was determined for each stratum of 20 complement genetic variants. In SEED, 484 individuals developed AMD and 216 showed progression over 6 years. In the UK Biobank, 913 participants developed AMD over 11 years. rs1061170 variant (complement factor H gene) was the only variant for which we found a protective effect in both populations. This effect was found in individuals carrying at least one C allele in SEED (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.19-0.87) and in individuals carrying two C alleles in UK Biobank (hazard ratio [HR] = 0.65; 95% CI, 0.45-0.93). These effects corresponded to a 50% and 35% decrease in AMD risk, respectively. Our study highlights the potential for personalized therapy for AMD based on complement genotyping.
Authors
- Sahil Thakur (ORCID: https://orcid.org/0000-0002-7948-6992)
- Charumathi Sabanayagam (ORCID: https://orcid.org/0000-0002-4042-4719)
- Simon Nusinovici (ORCID: https://orcid.org/0000-0002-9599-5818)
- Usha Chakravarthy (ORCID: https://orcid.org/0000-0002-2606-3734)
- Kelvin Yi Chong Teo (ORCID: https://orcid.org/0000-0002-7458-7081)
- Qiao Fan (ORCID: https://orcid.org/0000-0002-2762-8346)
- Can Can Xue (ORCID: https://orcid.org/0000-0002-2747-6215)
- Ching‐Yu Cheng (ORCID: https://orcid.org/0000-0003-0655-885X)
- David L. Silver (ORCID: https://orcid.org/0000-0002-7289-9890)
- Hengtong Li (ORCID: https://orcid.org/0000-0002-3843-7174)
- Tien Yin Wong (ORCID: https://orcid.org/0000-0002-8448-1264)
- Chui Ming Gemmy Cheung (ORCID: https://orcid.org/0000-0003-3358-3516)
- Yih Chung Tham (ORCID: https://orcid.org/0000-0002-6752-797X)
- Xiaomeng Wang (ORCID: https://orcid.org/0000-0002-1036-2764)
Institutions
- Agency for Science, Technology and Research (SG)
- Queen's University Belfast (GB)
- National University of Singapore (SG)
- Singapore National Eye Center (SG)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Institute of Molecular and Cell Biology (SG)
Publication Details
- Journal
- iScience
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1016/j.isci.2024.111344
- Citations
- 6
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- Agency for Science, Technology and Research
- Medical Research Council
- National Medical Research Council