Development of chiral ferrocenyl P,P,N,N,O-ligands for ruthenium-catalyzed asymmetric hydrogenation of ketones
A new type of ferrocenyl P,P,N,N,O-ligand has been developed through a one-step transformation. This represents a rare example of a ligand containing both chiral bisphosphine and diamine groups suitable for ruthenium-catalyzed asymmetric hydrogenation. Its ruthenium complex can be directly prepared by stirring the ligand and [Ru(benzene)Cl<sub>2</sub>]<sub>2</sub> at 90 °C in DMF for 4 hours. The catalyst showed high reactivity and enantioselectivity in the hydrogenation (AH) of simple ketones and α,β-unsaturated ketones, providing the corresponding chiral aryl alkyl alcohols and chiral allyl alcohols with up to 99% yield and 96% ee.
Authors
- Gen‐Qiang Chen (ORCID: https://orcid.org/0000-0003-2276-6800)
- Lei Xu (ORCID: https://orcid.org/0000-0002-5394-3905)
- Xumu Zhang (ORCID: https://orcid.org/0000-0001-5700-0608)
Institutions
- Southern University of Science and Technology (CN)
- Ji Hua Laboratory (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1039/d4ob01679c
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.16
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality
- National Key Research and Development Program of China