Prognostic characteristics and drug sensitivity analysis of hepatocellular carcinoma based on histone modification-related genes: a multi-omics integrated study revealing potential therapeutic targets and individualized treatment strategies
Our study provides a comprehensive understanding of HMs in HCC and establishes a robust prognostic signature. The HMRS not only stratifies patients into distinct risk groups but also offers insights into underlying molecular mechanisms, immune characteristics, and potential therapeutic strategies, paving the way for personalized medicine in HCC.
Authors
- Zheng Ding (ORCID: https://orcid.org/0000-0001-6689-4594)
- Rui Li (ORCID: https://orcid.org/0000-0002-9407-8591)
- Tianxiang Gu (ORCID: https://orcid.org/0000-0001-5640-7270)
- Ying Cheng (ORCID: https://orcid.org/0000-0003-2160-0673)
- Juan Chen (ORCID: https://orcid.org/0000-0001-6290-4062)
- Ping Sun (ORCID: https://orcid.org/0000-0002-6572-307X)
- He Sun (ORCID: https://orcid.org/0000-0003-0889-0514)
- Dian-Jie Zhou
- Kezhen Ou
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.3389/fphar.2024.1489469
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- China Medical University
- Department of Science and Technology of Liaoning Province