A 40‐week phase <scp>2B</scp> randomized, multicenter, double‐blind, placebo‐controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis
In this study, memantine did not impact ALS disease progression or neuropsychiatric symptoms. Trials with remote enrollment may help trial participation and success.
Authors
- Duaa Jabari
- Tiffany Schwasinger‐Schmidt (ORCID: https://orcid.org/0000-0002-6084-7866)
- Suzan A. Moser
- Zachary Simmons (ORCID: https://orcid.org/0000-0001-8574-5332)
- James Grogan (ORCID: https://orcid.org/0000-0001-6867-5643)
- Nick Olney
- Seymour Katz (ORCID: https://orcid.org/0000-0002-3492-9200)
- Richard J. Barohn (ORCID: https://orcid.org/0000-0002-0383-6845)
- Namita Goyal (ORCID: https://orcid.org/0000-0002-1713-545X)
- Mazen M. Dimachkie (ORCID: https://orcid.org/0000-0002-7148-989X)
- Kimberly Goslin
- Robert Bowser (ORCID: https://orcid.org/0000-0001-5404-7259)
- Edward J. Kasarskis (ORCID: https://orcid.org/0000-0001-5584-7506)
- Omar Jawdat
- Dan H. Moore (ORCID: https://orcid.org/0000-0002-5860-0127)
- Jeffrey Statland (ORCID: https://orcid.org/0000-0003-0790-5315)
- Salman Bhai (ORCID: https://orcid.org/0000-0003-4702-9380)
- Michael D. Weiss (ORCID: https://orcid.org/0000-0003-4064-1032)
- Michael Pulley (ORCID: https://orcid.org/0000-0003-1879-725X)
- Raghav Govindarajan (ORCID: https://orcid.org/0000-0003-0419-9072)
- Andrew Heim (ORCID: https://orcid.org/0009-0003-0845-6635)
- Todd Levine
- Yessar Hussain
- Maureen Walsh
- Tania Papsdorf
- Aziz Shibani
Institutions
- Lawrence Livermore National Laboratory (US)
- Cedars-Sinai Medical Center (US)
- Barrow Neurological Institute (US)
- University of Kentucky (US)
- University of Kansas (US)
- Providence College (US)
- University of Washington (US)
- University of California, Irvine (US)
- Texas Health Dallas (US)
- University of Florida (US)
- Wichita State University (US)
- Dell Children's Medical Center of Central Texas (US)
- Syneos Health (United States) (US)
- MemorialCare Health System (US)
- University of Kansas Medical Center (US)
- HonorHealth (US)
- Barrow Brain and Spine (US)
- Texas Neurology (US)
- Institute for Exercise and Environmental Medicine (US)
- DELL (United States) (US)
- Wichita Clinic (US)
- Texas Nerve and Paralysis Institute (US)
- University of Missouri (US)
- Penn State Milton S. Hershey Medical Center (US)
- The University of Texas at Austin (US)
- The University of Texas Southwestern Medical Center (US)
- Florida College (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1002/mus.28287
- Citations
- 4
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- U.S. Food and Drug Administration