Exploring the value of hybrid capture-based next-generation sequencing technology in the suspected diagnosis of bloodstream infections
Our study demonstrates the high accuracy of probe capture sequencing technology compared to blood cultures in the identification of pathogenic microorganisms in BSI upon final clinical diagnosis. Among the different sample types, white blood cell samples had a lower clinical compliance rate compared to plasma samples, possibly due to the higher host rate in cell samples, which impairs the sensitivity of pathogen detection.
Authors
- Jiachang Chen (ORCID: https://orcid.org/0000-0002-7488-1707)
- Jianying Yuan (ORCID: https://orcid.org/0000-0001-5357-2385)
- Xinyuan Liu (ORCID: https://orcid.org/0000-0002-9754-0593)
- Xiaojun Lin (ORCID: https://orcid.org/0009-0005-6046-7993)
- Zhihua Gan (ORCID: https://orcid.org/0000-0001-9906-9638)
- Lei Rong (ORCID: https://orcid.org/0000-0001-9260-5012)
- Chaohui Hu
- Yingzhen Li
- Zengshun Lin
- Jun Liu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Kingmed Diagnostics (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-11-08
- DOI
- https://doi.org/10.7717/peerj.18471
- Citations
- 4
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 1.52