Palladium Catalyzed Cyanation of Diaryl Sulfoxides
Aryl nitriles are highly versatile and useful compounds. A palladium-catalyzed cyanation of diaryl sulfoxides using bench-stable Zn(CN)<sub>2</sub> as the cyanating reagent has been developed. The reaction proceeded well using Pd(OAc)<sub>2</sub> as the catalyst with the inexpensive ligand PCy<sub>3</sub> in the presence of <i>t</i>-BuONa. The method has a broad scope of substrates and is scalable. The regioselective cyanation of unsymmetrical diaryl sulfoxides was observed at the side of electron-deficient and more steric hindered aryl groups.
Authors
- Xianchao Qiu
- Benqiang Cui (ORCID: https://orcid.org/0000-0002-3692-0170)
- Yanhui Shi
- Changsheng Cao
- Guangcai Qu
Institutions
- Jiangsu Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1021/acs.joc.4c02506
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- Jiangsu Normal University