Investigating potential drug targets for IgA nephropathy and membranous nephropathy through multi-queue plasma protein analysis: a Mendelian randomization study based on SMR and co-localization analysis
Genetically influenced plasma levels of PLA2R1 and NFKB1 impact MN risk, while FCGR3B and BTN3A1 levels are causally linked to IgAN risk, suggesting potential drug targets for further clinical exploration, notably BTN3A1 for IgAN.
Authors
- Ying Gao (ORCID: https://orcid.org/0000-0003-1411-5047)
- Shirui Yang (ORCID: https://orcid.org/0009-0006-9304-2702)
- Jianbo Xu (ORCID: https://orcid.org/0000-0001-9143-168X)
- Xinyi Xu (ORCID: https://orcid.org/0000-0002-3604-7906)
- Fang–Ying Wu (ORCID: https://orcid.org/0000-0002-8524-7904)
- Lu Xiao (ORCID: https://orcid.org/0000-0003-1934-4711)
- Changhong Miao (ORCID: https://orcid.org/0000-0002-7199-6760)
Institutions
- Zhejiang Chinese Medical University (CN)
- Tianjin University of Traditional Chinese Medicine (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- BioData Mining
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s13040-024-00405-w
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China