Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity
Our results demonstrate that miR203a is just one paradigmatic TLR7-activating miRNA among the hundreds released by UV-irradiated keratinocytes, which altogether trigger pDC activation in psoriatic conditions. This represents the first evidence that cell damage shifts the miRNA content of sEVs towards a TLR7-activating cargo capable to propagate inflammation and immunity, offering strong support to the physiological role of systemic miRNA-based cell-to-cell communication.
Authors
- Paolo Bergese (ORCID: https://orcid.org/0000-0002-4652-2168)
- Carlo Selmi (ORCID: https://orcid.org/0000-0002-0323-0376)
- Angela Ceribelli (ORCID: https://orcid.org/0000-0001-5116-4724)
- Stefano Calza (ORCID: https://orcid.org/0000-0003-4996-7995)
- Laura Tiberio (ORCID: https://orcid.org/0000-0003-0482-9898)
- Annalisa Del Prete (ORCID: https://orcid.org/0000-0002-3738-412X)
- Barbara Mariotti (ORCID: https://orcid.org/0000-0001-5831-8319)
- Flavia Bazzoni (ORCID: https://orcid.org/0000-0001-6768-8012)
- Silvano Sozzani (ORCID: https://orcid.org/0000-0002-3144-8743)
- Tiziana Schioppa (ORCID: https://orcid.org/0000-0002-6303-6065)
- Valentina Salvi (ORCID: https://orcid.org/0000-0003-4802-1524)
- Daniela Bosisio (ORCID: https://orcid.org/0000-0001-6276-5365)
- Veronica Gianello
- Silvia Alacqua (ORCID: https://orcid.org/0000-0003-2611-1844)
- Carolina Gaudenzi (ORCID: https://orcid.org/0000-0003-1731-8747)
- Gaia Giongrandi
Institutions
- University of Verona (IT)
- Humanitas University (IT)
- Istituto Pasteur (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s12964-024-01924-z
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Università degli Studi di Brescia
- Ministero dell'Università e della Ricerca