Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimaging
Cancer phototheranostics is a new mode of precise treatment based on fluorescent and photothermal imaging (PTI), combined with photodynamic (PDT) and photothermal therapy (PTT). Herein, we designed a photoactive Pt(IV) prodrug Pt-1 with BODIPY-based triplet photosensitizer as an axial ligand that exhibits cytotoxic effects through both PDT and photoactivated chemotherapy (PACT). Based on the Pt-1 prodrug, we developed a multifunctional theranostic nanoplatform Pt-NPs with combined PDT/PTT activity, capable of light-induced cisplatin release and suitable for photothermal and fluorescent tumor imaging. Upon 660 nm laser irradiation, Pt-NPs efficiently causes regional hyperpyrexia, with a photothermal conversion efficiency of 42.1%. Synergistically, Pt-NPs acts as a PDT type I agent. In vivo PTI studies have shown bright fluorescence of the CT-26 tumor after intravenous injection of Pt-NPs, indicating accumulation and retention of Pt-NPs in the tumor. This is the first example of PTT/PDT-active NPs based on Pt(IV) prodrug capable of photoinduced release of cisplatin. This strategy of the synergistic light-induced PDT/PTT/PACT action of Pt-NPs provides a new platform for the future design of phototheranostic agents for enhanced tumor treatment and imaging.
Authors
- Dmitry A. Skvortsov (ORCID: https://orcid.org/0000-0001-8336-8596)
- Вита Н. Никитина (ORCID: https://orcid.org/0000-0001-6821-6949)
- Yu. V. Maksimova (ORCID: https://orcid.org/0000-0002-9094-1714)
- Maxim A. Abakumov (ORCID: https://orcid.org/0000-0003-2622-9201)
- Dmitry A. Bunin
- E. V. Khaydukov (ORCID: https://orcid.org/0000-0002-3900-2949)
- Alexander S. Erofeev (ORCID: https://orcid.org/0000-0002-6631-821X)
- Elena Kimovna Beloglazkina (ORCID: https://orcid.org/0000-0001-6796-8241)
- Alexander G. Martynov (ORCID: https://orcid.org/0000-0002-2192-7134)
- E. M. Trifanova (ORCID: https://orcid.org/0000-0003-4320-6917)
- И. А. Родин (ORCID: https://orcid.org/0000-0002-0588-6870)
- Vadim S. Pokrovsky (ORCID: https://orcid.org/0000-0003-4006-9320)
- M. E. Stepanov (ORCID: https://orcid.org/0000-0002-0332-1235)
- Roman Akasov (ORCID: https://orcid.org/0000-0001-6486-8114)
- Mikhail F. Vokuev (ORCID: https://orcid.org/0000-0002-1733-4969)
- Olga Olegovna Krasnovskaya (ORCID: https://orcid.org/0000-0002-4948-2747)
- Vladislav Bykusov
- А. С. Дубенский
- Daria A. Ipatova
- Petr V. Gorelkin (ORCID: https://orcid.org/0000-0002-4860-9013)
- Daniil V. Spector (ORCID: https://orcid.org/0000-0002-2726-2671)
- Gulalek Babayeva (ORCID: https://orcid.org/0000-0001-5781-7925)
- Regina Kuanaeva (ORCID: https://orcid.org/0009-0003-1948-7381)
- Yulia A. Isaeva
- Ilia Kuzmichev
- T. R. Uskova
- Anastasia Zharova
Institutions
- National University of Science and Technology (RU)
- Peoples' Friendship University of Russia (RU)
- D. Mendeleyev University of Chemical Technology of Russia (RU)
- Moscow State Pedagogical University (RU)
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Pirogov Russian National Research Medical University (RU)
- Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences (RU)
- Institute of Synthetic Polymeric Materials (RU)
- Geological Institute (RU)
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
- National Medical Research Center of Dentistry and Maxillofacial Surgery (RU)
Publication Details
- Journal
- ACS Applied Nano Materials
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1021/acsanm.4c04680
- Citations
- 5
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.92
Funders
- Russian Science Foundation
- Ministry of Science and Higher Education of the Russian Federation