Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms
• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14<sup>+</sup> cells, whereas CMML exhibits heightened inflammation, highlighting distinct disease mechanisms.
Authors
- Eleftheria Lamprianidou (ORCID: https://orcid.org/0000-0001-6637-4281)
- Anastasia Filia (ORCID: https://orcid.org/0000-0003-3824-2745)
- Haralampos Hatzikirou (ORCID: https://orcid.org/0000-0002-1270-7885)
- Ιoannis Kotsianidis (ORCID: https://orcid.org/0000-0001-7668-0186)
- Chrysa Kymparidou
- Menelaos Papoutselis (ORCID: https://orcid.org/0000-0002-1686-4992)
- Despoina Dimitriou
- Antonios Chatzigeorgiou (ORCID: https://orcid.org/0000-0002-7039-4223)
- Nikolaos Paschalidis (ORCID: https://orcid.org/0000-0001-6278-4144)
- Giannis Vatsellas (ORCID: https://orcid.org/0000-0002-1631-1060)
- Athanasios Tasis (ORCID: https://orcid.org/0000-0002-8411-961X)
- Christina Misidou (ORCID: https://orcid.org/0000-0002-7771-7419)
- Konstantinos Liapis (ORCID: https://orcid.org/0000-0003-1165-9639)
- Ioannis Mitroulis (ORCID: https://orcid.org/0000-0002-9991-2362)
- Theodoros Spyropoulos (ORCID: https://orcid.org/0009-0003-5325-8451)
- Maria Grigoriou (ORCID: https://orcid.org/0000-0001-5383-4138)
- Panagiotis Papazoglou
Institutions
- Democritus University of Thrace (GR)
- Khalifa University of Science and Technology (AE)
- National and Kapodistrian University of Athens (GR)
- Biomedical Research Foundation of the Academy of Athens (GR)
- University Hospital of Alexandroupolis (GR)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1002/eji.202451387
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Khalifa University of Science, Technology and Research
- Servier
- Hellenic Foundation for Research and Innovation