Common Cold Coronavirus 229E Induces Higher Interferon Stimulating Gene Responses in Human Nasal Epithelial Cells from Patients with Chronic Rhinosinusitis with Polyposis
This study paradoxically demonstrates that ALI cultures from patients with CRSwNP are more efficient at clearing the common cold HCoV-229E virus compared to controls. We also demonstrate significantly increased ISG mRNA expression following HCoV-229E infection in CRSwNP. These findings call for further investigation into the effect of unimpaired interferon signaling on the type 2 inflammatory environment in patients with CRSwNP.
Authors
- Susan R. Weiss (ORCID: https://orcid.org/0000-0002-8155-4528)
- Noam Cohen (ORCID: https://orcid.org/0009-0003-7047-8843)
- Jennifer E. Douglas (ORCID: https://orcid.org/0000-0002-3634-2067)
- Nithin D. Adappa (ORCID: https://orcid.org/0000-0002-0339-8769)
- Elizabeth Sell (ORCID: https://orcid.org/0000-0002-9658-1107)
- Michael A. Kohanski (ORCID: https://orcid.org/0000-0001-8399-364X)
- David M. Renner
- Li Tan (ORCID: https://orcid.org/0000-0003-4352-654X)
- David W. Kennedy (ORCID: https://orcid.org/0000-0002-0171-1336)
- Robert J. Lee
- James Palmer
- John V. Bosso
Institutions
- Monell Chemical Senses Center (US)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- American Journal of Rhinology and Allergy
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1177/19458924241276274
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health