ANK Deficiency-Mediated Cytosolic Citrate Accumulation Promotes Aortic Aneurysm
Our studies define the pathogenic role of ANK deficiency-induced cytosolic citrate accumulation in AA pathogenesis and an undescribed citrate-related proinflammatory VSMC phenotype. Targeting ANK-mediated citrate transport may emerge as a novel diagnostic and therapeutic strategy in AA.
Authors
- Shiyu Yang
- Wei Kong (ORCID: https://orcid.org/0000-0001-6720-6810)
- Hao Wu (ORCID: https://orcid.org/0000-0003-4915-883X)
- Yi Fu (ORCID: https://orcid.org/0000-0002-8832-9331)
- J. Li (ORCID: https://orcid.org/0000-0002-6448-9859)
- Ze Gong (ORCID: https://orcid.org/0000-0002-5247-3948)
- Luyang Sun (ORCID: https://orcid.org/0000-0003-3917-473X)
- Yiping Shen
- Wenqiang Li (ORCID: https://orcid.org/0000-0002-0833-246X)
- Yanjie Li (ORCID: https://orcid.org/0000-0002-9545-6179)
- Lin He (ORCID: https://orcid.org/0000-0001-7429-8012)
- Zhiqing Li (ORCID: https://orcid.org/0000-0002-5222-6867)
- Jiaqi Huang (ORCID: https://orcid.org/0000-0002-3778-2398)
- Yiran Li (ORCID: https://orcid.org/0000-0002-6339-5324)
- Liu Yang (ORCID: https://orcid.org/0009-0005-2129-4946)
- Fang Yu
- X. Yang (ORCID: https://orcid.org/0000-0001-5221-0868)
- Qinfeng Xu (ORCID: https://orcid.org/0000-0002-9710-8928)
- Hao Liu (ORCID: https://orcid.org/0000-0002-2366-9554)
Institutions
- Jiangnan University (CN)
- Zhejiang Wanli University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Anzhen Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1161/circresaha.124.325152
- Citations
- 20
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.38