Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats
Our study provides evidence for the higher anti-inflammatory efficacy of celecoxib compared to rofecoxib in mesenteric I/R injury, which is likely due to its lower selectivity for COX-2. However, even high-dose celecoxib was unable to reduce the mucosal damage. Our results suggest that selective COX-2 inhibitors have only limited therapeutic value in intestinal I/R injury.
Authors
- Anna Jakab (ORCID: https://orcid.org/0000-0001-5707-9475)
- Andrea Kelemen (ORCID: https://orcid.org/0009-0009-8542-8463)
- András S. Tóth
- Zsuzsanna O. Demeter
- Zoltán Zádori (ORCID: https://orcid.org/0000-0001-7312-618X)
- Barbara Hutka
- Szilvia B. László
- Arezoo Haghighi
- Klára Gyires
- Tamás Hegyes
- Gerda Wachtl
Institutions
- Semmelweis University (HU)
- Military Hospital (PK)
- Gedeon Richter (Hungary) (HU)
- Pázmány Péter Catholic University (HU)
- Central Military Hospital (NL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.3389/fphar.2024.1468579
- Citations
- 3
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Servier