Genetic Alterations in Chromatin Regulatory Genes in Upper Tract Urothelial Carcinoma and Urothelial Bladder Cancer
Since genetic alterations of the chromatin pathway genes are important in both UTUC and UCB, they could serve as potential biomarkers for predicting disease progression and therapeutic targets. Differences in mutation frequencies of DDR pathway, TMB, CNV, and TCR might be the contributing factors for the distinct responses to immune checkpoint inhibitor (ICI) between UTUC and UCB.
Authors
- Qiang Ran (ORCID: https://orcid.org/0000-0002-4535-0229)
- Qiang Ma (ORCID: https://orcid.org/0000-0002-2302-9813)
- Jun Qin (ORCID: https://orcid.org/0000-0002-2263-128X)
- Luofu Wang (ORCID: https://orcid.org/0000-0003-2314-8369)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-4627-8625)
- Dianzheng Zhang (ORCID: https://orcid.org/0000-0001-7732-9689)
- Dali Tong (ORCID: https://orcid.org/0000-0001-9698-8671)
- Weihua Lan (ORCID: https://orcid.org/0000-0003-1186-195X)
- Jun Jiang (ORCID: https://orcid.org/0000-0002-8931-9872)
- Xuzhi Yan (ORCID: https://orcid.org/0000-0002-8724-4379)
- Haoyang Li (ORCID: https://orcid.org/0000-0003-3164-8240)
- Ze Wang (ORCID: https://orcid.org/0000-0002-8581-0576)
- Yao Zhang (ORCID: https://orcid.org/0000-0002-0776-1764)
- Qian Yan (ORCID: https://orcid.org/0009-0008-7483-0572)
- Hualiang Xiao (ORCID: https://orcid.org/0000-0001-7960-5536)
- Jing Xu (ORCID: https://orcid.org/0000-0002-6530-5070)
- Yapeng Wang (ORCID: https://orcid.org/0000-0002-2923-1406)
- Qiuli Liu (ORCID: https://orcid.org/0000-0002-9532-5654)
- Junhao Jin
- Haiyang Xiao
Institutions
- Philadelphia College of Osteopathic Medicine (US)
- Army Medical University (CN)
- Daping Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Center for Excellence in Molecular Cell Science (CN)
- University of Chinese Academy of Sciences (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1002/cam4.70398
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing