The Risk Genes S1PR5, CMC1, and ASAH1 as Potential Targets for the Diagnosis, Immunotherapy, and Treatment of Colon Adenocarcinoma by Single-Cell and Bulk RNA Sequencing Analysis
In this study, using scRNA-seq and bulk RNA-seq data, we created a risk model to predict the prognosis and effectiveness of immunotherapy in patients with COAD. In addition, we have discovered three model genes (S1PR5, CMC1, and ASAH1) that have not been reported before. These genes have the potential to be novel therapeutic targets in Colorectal Cancer (CRC). These findings suggest that this model could be used to evaluate the prognostic risk and identify potential targets for COAD patient treatment.
Authors
- Yihang Yuan (ORCID: https://orcid.org/0000-0002-6658-8535)
- Weidong Hu (ORCID: https://orcid.org/0000-0003-3646-8572)
- Feng Cai
- Zhenghai Zhu
- Zipeng Xu (ORCID: https://orcid.org/0000-0001-7822-6032)
- Jun Gong (ORCID: https://orcid.org/0000-0001-9744-7201)
- Chaobo Chen (ORCID: https://orcid.org/0000-0001-5963-5295)
- Ge Chen (ORCID: https://orcid.org/0000-0002-3109-3145)
- G TONG
Institutions
- Nanjing Drum Tower Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-11-07
- DOI
- https://doi.org/10.2174/0109298673331144241009082052
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85