Dynamics of the gut microbiome in individuals at risk of rheumatoid arthritis: a cross-sectional and longitudinal observational study
These data suggest conflicting reports on Prevotellaceae overabundance are likely due to sampling within a heterogeneous population along a dynamic disease spectrum, with certain Prevotellaceae strains/clades possibly contributing to the establishment and/or progression of RA. Gut microbiome changes in RA may appear at the transition to clinical arthritis as a late manifestation, and it remains unclear whether they represent a primary or secondary phenomenon.
Authors
- Ian B. Jeffery (ORCID: https://orcid.org/0000-0001-9183-7292)
- Paul Emery (ORCID: https://orcid.org/0000-0002-7429-8482)
- Mark H. Wilcox (ORCID: https://orcid.org/0000-0002-4565-2868)
- Kulveer Mankia (ORCID: https://orcid.org/0000-0002-7945-6582)
- Christopher Rooney (ORCID: https://orcid.org/0000-0002-3640-853X)
Institutions
- University of Leeds (GB)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1136/ard-2024-226362
- Citations
- 18
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Leeds Hospital Charitable Foundation
- Versus Arthritis
- Leeds Biomedical Research Centre