Assessing acute kidney injury risk after COVID vaccination and infection in a large cohort study
Acute kidney injury (AKI) has been noticed after both COVID-19 vaccination and infection, affecting risk-benefit evaluations and vaccine hesitancy. We conducted a large-scale N3C cohort study to compare AKI incidence following COVID-19 vaccination and infection. Participants from December 2020 to August 2023 were divided into two groups based on their initially observed COVID-19 antigen exposure: COVID-19 vaccination group (n = 2,953,219) and COVID-19 infection group (n = 3,616,802). AKI was defined by diagnostic codes and serum creatinine changes within a 30 day follow-up window after exposure. The absolute risk of AKI was 0.66% in the vaccination group versus 4.88% in the infection group. After adjusting for various confounders, COVID-19 infection was associated with a significantly higher risk of AKI than COVID-19 vaccination (aHR = 10.31, P < 0.001). Our study reveals that COVID-19 vaccination is associated with a significant lower AKI risk compared to COVID-19 infection.
Authors
- Yongqun He (ORCID: https://orcid.org/0000-0001-9189-9661)
- Farrukh M. Koraishy (ORCID: https://orcid.org/0000-0001-6974-5674)
- Xianwei Ye (ORCID: https://orcid.org/0000-0002-2330-3907)
- Christopher G. Chute (ORCID: https://orcid.org/0000-0001-5437-2545)
- Yun Han (ORCID: https://orcid.org/0000-0002-3847-3757)
- Chuan Zhou (ORCID: https://orcid.org/0000-0002-0609-1658)
- Yuanyi Pan (ORCID: https://orcid.org/0000-0002-0595-4335)
- Jie Zheng (ORCID: https://orcid.org/0000-0002-2999-0103)
- Lili Zhao (ORCID: https://orcid.org/0000-0001-5501-0028)
Institutions
- Johns Hopkins University (US)
- Guiyang Medical University (CN)
- Guizhou University (CN)
- University of Michigan (US)
- Beaumont Health (US)
- Affiliated Hospital of Guizhou Medical University (CN)
- Michigan Center for Translational Pathology (US)
- Guizhou Provincial People's Hospital (CN)
- Stony Brook University (US)
Publication Details
- Journal
- npj Vaccines
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1038/s41541-024-00964-3
- Citations
- 6
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Bill and Melinda Gates Foundation
- Yale University
- University of Southern California
- Children's Hospital of Philadelphia
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- University of Nebraska Medical Center
- Vanderbilt University
- University of Miami
- University of Pennsylvania
- Ohio State University
- Emory University
- Tufts Medical Center
- NYU Langone Medical Center
- University of Wisconsin-Madison
- Northwestern University
- Wake Forest University
- Cincinnati Children's Hospital Medical Center
- Vanderbilt Institute for Clinical and Translational Research
- University of Chicago
- University of Minnesota
- Washington University in St. Louis
- University of Michigan
- Loyola University Chicago
- University of Utah
- University of Washington
- University of Texas Medical Branch
- Tulane University
- University of Pittsburgh
- University of Oklahoma
- Institute for Translational Medicine and Therapeutics
- Institute of Clinical and Translational Sciences
- Georgetown University
- University of Rochester
- University of Cincinnati
- Pennsylvania State University
- Rush University
- Virginia Commonwealth University
- Southern California Clinical and Translational Science Institute
- West Virginia University
- Montana State University
- Rutgers, The State University of New Jersey
- MedStar Health Research Institute
- Georgetown-Howard Universities Center for Clinical and Translational Science
- University of Texas Health Science Center at Houston
- Vanderbilt University Medical Center
- Institute of Translational Health Sciences
- Penn State Clinical and Translational Science Institute
- Louisiana Clinical and Translational Science Center
- Ochsner Health
- West Virginia Clinical and Translational Science Institute
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Stony Brook University
- National Institutes of Health
- Centers for Disease Control and Prevention
- University of Illinois at Urbana-Champaign
- Institute for Clinical and Translational Research, University of Wisconsin, Madison
- University of California, Los Angeles
- Weill Cornell Medical College
- University of California, Davis
- Oregon Clinical and Translational Research Institute
- University of North Carolina at Chapel Hill
- University of California, San Diego
- University of Oklahoma Health Sciences Center
- University of California, San Francisco
- Michigan Institute for Clinical and Health Research
- University of Texas Health Science Center at San Antonio
- University of California, Irvine
- Leonard M. Miller School of Medicine
- Center for Clinical and Translational Research
- University of Colorado Denver
- Center for Clinical and Translational Science, University of Massachusetts
- Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston
- Translational Research Institute, University of Arkansas for Medical Sciences
- Clinical and Translational Science Institute, University of Florida
- Clinical and Translational Science Center, University of New Mexico
- National Center for Advancing Translational Sciences
- Institute for Integration of Medicine and Science
- Colorado Clinical and Translational Sciences Institute
- Yale Center for Clinical Investigation, Yale School of Medicine
- Institute for Clinical and Translational Science, University of California, Irvine
- Wake Forest Clinical and Translational Science Institute, Wake Forest School of Medicine