Somatic GNAS mutations in acromegaly: prevalence, clinical features and gender differences
GNAS mutations are prevalent among Chinese acromegaly patients, correlating with reduced pituitary tumor sizes and enhanced GH secretion functions. Our findings underscore the influence of gender on the clinical manifestations of GNAS mutations. Accordingly, we recommend that future clinical and foundational research studies on acromegaly give heightened consideration to gender-specific differences.
Authors
- Hui Miao (ORCID: https://orcid.org/0000-0002-5446-1756)
- Xiaoan Ke (ORCID: https://orcid.org/0000-0002-4182-2890)
- Lian Duan (ORCID: https://orcid.org/0000-0002-4213-474X)
- Huijuan Zhu (ORCID: https://orcid.org/0000-0001-5172-6870)
- Fengying Gong (ORCID: https://orcid.org/0000-0002-3832-5674)
- Bing Xing
- Kan Deng (ORCID: https://orcid.org/0000-0001-9571-3705)
- Feng Feng (ORCID: https://orcid.org/0000-0002-3507-1154)
- Wei Lian (ORCID: https://orcid.org/0000-0002-8023-5138)
- Linjie Wang (ORCID: https://orcid.org/0000-0002-9548-0398)
- Yong Yao (ORCID: https://orcid.org/0000-0001-6982-8832)
- Xin Lian (ORCID: https://orcid.org/0000-0003-4609-3225)
- Meiping Chen (ORCID: https://orcid.org/0000-0003-1998-9915)
- Hui You
- Yamei Yang
- Mao Xinxin
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Peking Union Medical College Hospital (CN)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1530/ec-24-0266
- Citations
- 3
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College