Ligand‐Free Zn Catalyzed Synthesis of Functionalized Indoloacridines

Abstract An efficient, ligand‐free, and Zn‐catalyzed dehydrogenation of acridinol/ cyclization of imine product/ dehydrogenative C(sp 3 )‐H functionalization utilizing ChCl‐based deep eutectic solvent system for the assembly of functionalized indoloacridines 9 is reported. The protocol features mild reaction conditions, VOCs free process, broad substrate scope, and applicable gram‐scale synthesis. Furthermore, absorption and solvatochromism properties were explored for the synthesized compounds.

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Publication Details

Journal
Asian Journal of Organic Chemistry
Published
2024-11-08
DOI
https://doi.org/10.1002/ajoc.202400482
Citations
2
Primary Topic
Catalytic C–H Functionalization Methods
Type
article
Field-Weighted Citation Impact
0.50
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article

Ligand‐Free Zn Catalyzed Synthesis of Functionalized Indoloacridines

Fazlurrahman Khan, Nagarajan Sambavi
2 citations
Asian Journal of Organic Chemistry
Catalytic C–H Functionalization Methods
0.50
article

Ligand‐Free Zn Catalyzed Synthesis of Functionalized Indoloacridines

Fazlurrahman Khan, Nagarajan Sambavi
article en
2 citations

Abstract

Abstract An efficient, ligand‐free, and Zn‐catalyzed dehydrogenation of acridinol/ cyclization of imine product/ dehydrogenative C(sp 3 )‐H functionalization utilizing ChCl‐based deep eutectic solvent system for the assembly of functionalized indoloacridines 9 is reported. The protocol features mild reaction conditions, VOCs free process, broad substrate scope, and applicable gram‐scale synthesis. Furthermore, absorption and solvatochromism properties were explored for the synthesized compounds.

Asian Journal of Organic ChemistryVol. 14(1)
Vellore Institute of Technology University (IN)
Openalex Percentile: Top 38%
Catalytic C–H Functionalization Methods
0.50
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