Prognostic algorithm for risk assessment of retinal vein occlusion under geomagnetic perturbations

Aim. To develop a screening and prognostic algorithm for assessing the risk of retinal vein occlusion in patients with arterial hypertension under the conditions of geomagnetic disturbances. Material and methods. In total, 1512 patients with arterial hypertension of 1–4 stages were examined. Within the period of three years, 391 patients developed retinal venous occlusions. The parameters of systemic and regional hemodynamics in these patients, as well as ocular microcirculatory function, were compared both in a magnetically calm environment and during geomagnetic disturbances. To simulate the response of microcirculatory bed to stress, a functional pharmacological instillation test with a 10% Irifrin solution was performed. To assess the geomagnetic situation, the К р index was used, which objectively characterizes fluctuations of the Earth’s magnetic field over a 3h time interval. The International Classification of К р values was used. Results. For statistical analysis, 78 studied signs of systemic, regional hemodynamics, and microcirculation were selected. The prognostic significance of 30 studied signs was revealed. A training group (1434 people) and an examination group (78 people) were formed. Based on the training group, a predictive algorithm was formed. A number of regularities were established, which can be used to create a system for risk assessment of retinal vein thrombosis during geomagnetic disturbances in patients with hypertension. To determine the risk of retinal vein occlusion, a coefficient was developed. The algorithm showed the sensitivity and specificity of 89% and 94%, respectively. Conclusion. A prognostic algorithm with high sensitivity and specificity for assessing the risk of occlusive lesions of the retinal veins during geomagnetic disturbances in patients with arterial hypertension is proposed.