GABA/Glutamate Neuron Differentiation Imbalance and Increased AKT/mTOR Signaling in CNTNAP2−/− Cerebral Organoids
These findings potentially highlight a shared mechanism in the early cortical development of various forms of ASD, further elucidate the role of CNTNAP2 in ASD pathophysiology and cortical development, and pave the way for targeted therapies that use cerebral organoids as preclinical models.
Authors
- Theoklitos Amvrosiadis (ORCID: https://orcid.org/0000-0002-6975-5888)
- Apostolos Avgeropoulos (ORCID: https://orcid.org/0000-0002-6203-9942)
- Christos G. Gkogkas (ORCID: https://orcid.org/0000-0001-6281-3419)
- Georgia Voudouri (ORCID: https://orcid.org/0009-0007-6000-7940)
- Elpida Statoulla (ORCID: https://orcid.org/0000-0003-3419-3253)
- Kleanthi Chalkiadaki (ORCID: https://orcid.org/0000-0001-7951-8942)
- Maria Zafeiri (ORCID: https://orcid.org/0000-0001-9879-6753)
- Niki Theodoridou (ORCID: https://orcid.org/0000-0003-3194-594X)
- Martina Samiotaki (ORCID: https://orcid.org/0000-0001-9952-0636)
- John O. Mason (ORCID: https://orcid.org/0000-0002-0489-2400)
- Dimitrios Moschovas (ORCID: https://orcid.org/0000-0003-2209-8355)
- Alexandra Typou
Institutions
- University of Ioannina (GR)
- Alexander Fleming Biomedical Sciences Research Center (GR)
- Foundation for Research and Technology Hellas (GR)
- University of Edinburgh (GB)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1016/j.bpsgos.2024.100413
- Citations
- 8
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- Hellenic Foundation for Research and Innovation