Genome‐wide transcriptome analysis of Aβ deposition on PET in a Korean cohort
Dysregulated genes were associated with amyloid beta (Aβ) deposition on positron emission tomography in a Korean cohort. Dysregulated genes in Alzheimer's disease were replicated in an independent Korean cohort. Gene network modules were associated with Aβ deposition. Natural killer (NK) cell proportion in blood was associated with Aβ deposition. Dysregulated genes were related to a NK cell-mediated immunity.
Authors
- SangYun Kim (ORCID: https://orcid.org/0000-0002-9101-5704)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- MinYoung Cho
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Tamina Park
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Hongyu Gao (ORCID: https://orcid.org/0000-0001-8633-3604)
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Thea Rosewood (ORCID: https://orcid.org/0000-0001-7025-0222)
- Soumilee Chaudhuri (ORCID: https://orcid.org/0000-0002-8488-6114)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Hannah Craft
- Yunlong Liu (ORCID: https://orcid.org/0000-0002-0185-9293)
- Min-Jeong Kim (ORCID: https://orcid.org/0000-0002-8709-1827)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee
- Yen‐Ning Huang
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-5759-8969)
- Yoon‐Keun Kim (ORCID: https://orcid.org/0000-0001-7610-7654)
- Young Ho Park (ORCID: https://orcid.org/0000-0002-2756-1786)
- Sang Won Han (ORCID: https://orcid.org/0000-0002-9503-1883)
- Jiyun Hwang
- Shiwei Liu
Institutions
- Seoul National University (KR)
- Hallym University (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Sacred Heart Hospital (NG)
- Korea National Institute of Health (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1002/alz.14348
- Citations
- 2
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Foundation for the National Institutes of Health
- Seoul National University
- Ministry of Science and ICT, South Korea
- National Institutes of Health
- National Institute on Aging