Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR
Our findings suggest that nanoparticle-mediated dual gene silencing can effectively overcome GBM radioresistance. This strategy has the potential to improve clinical outcomes in GBM treatment, proposing a promising therapeutic avenue for this challenging malignancy.
Authors
- Bohong Cen (ORCID: https://orcid.org/0000-0003-4879-6987)
- Xinghua Pan (ORCID: https://orcid.org/0000-0002-7421-8155)
- Yawei Yuan
- Baiyao Wang
- Zhongyuan Xu (ORCID: https://orcid.org/0000-0002-7397-4637)
- Chengcong Chen (ORCID: https://orcid.org/0000-0003-4012-4983)
- Guoqian Zhang
- Rong Li (ORCID: https://orcid.org/0000-0002-0540-6566)
- Zhiyong Li (ORCID: https://orcid.org/0000-0002-6814-9165)
- Jiän Zhang (ORCID: https://orcid.org/0000-0002-0557-886X)
- Aimin Ji (ORCID: https://orcid.org/0000-0002-8504-2327)
Institutions
- Nanfang Hospital (CN)
- Cell Technology (China) (HK)
- Guangzhou Medical University Cancer Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/ijn.s483252
- Citations
- 10
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 2.34