Duloxetine-Induced Sleep Bruxism and Tooth Fracture in Fibromyalgia

Duloxetine is a serotonin-norepinephrine reuptake inhibitor that is approved for the treatment of fibromyalgia. Duloxetine has many side effects such as nausea, somnolence, insomnia, decreased appetite, dry mouth, and constipation. Sleep bruxism is also a very rare side effect of duloxetine. In this case report, a case of a 35-year-old male patient who developed sleep bruxism in the 4th week after duloxetine use, and fracture of the 1st upper molar tooth which had previously undergone root canal treatment after severe bruxism in the 6th week was presented. Duloxetine treatment was stopped and treatment was continued with amitriptyline. The patient had a significant reduction in both bruxism and fibromyalgia symptoms after the amitriptyline treatment. Bruxism symptoms were not observed after one year of follow-up.