PM2.5 Promotes Macrophage-Mediated Inflammatory Response Through Airway Epithelial Cell-Derived Exosomal miR-155-5p
PM2.5 promotes Mφ inflammation by upregulating miRNA-155-5P in exosomes obtained from BEAS-2B cells through miR-155-5P/SOCS1/NF-κB pathway. Exosomal miRNAs mediate cellular communication between BEAS-2B cells and Mφ, which may be a new mechanism of PM2.5-stimulated pulmonary inflammatory response.
Authors
- Hui Xu (ORCID: https://orcid.org/0000-0002-3283-4638)
- Xin Li (ORCID: https://orcid.org/0000-0002-8898-9938)
- Ping Huang (ORCID: https://orcid.org/0000-0002-7391-1441)
- Xiaoju Liu (ORCID: https://orcid.org/0000-0002-5110-8949)
- Kai Liu (ORCID: https://orcid.org/0000-0002-5654-2613)
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s482509
- Citations
- 12
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 3.78
Funders
- National Natural Science Foundation of China