Oral LPCN 1148 improves sarcopenia and hepatic encephalopathy in male patients with cirrhosis: A randomized, placebo-controlled phase 2 trial
LPCN 1148 treatment improved sarcopenia and reduced the number of overt HE episodes in men with cirrhosis and sarcopenia awaiting liver transplant. These findings support additional research on the efficacy of LPCN 1148 in treating sarcopenia and preventing HE recurrence.
Authors
- Elizabeth J. Carey (ORCID: https://orcid.org/0000-0001-8580-2122)
- Parvez Mantry (ORCID: https://orcid.org/0000-0003-4829-6931)
- Kirti Shetty (ORCID: https://orcid.org/0000-0002-7725-6050)
- Christopher J. Danford (ORCID: https://orcid.org/0000-0003-0322-7705)
- Zachary Fricker (ORCID: https://orcid.org/0000-0001-5596-864X)
- Joseph Galati (ORCID: https://orcid.org/0000-0002-1871-0292)
- Anthony DelConte
- William M. Lee (ORCID: https://orcid.org/0000-0002-2783-5441)
- Arun Jayant Sanyal (ORCID: https://orcid.org/0000-0001-8682-5748)
- Joshua C. Weavil (ORCID: https://orcid.org/0000-0002-2032-8498)
- Jennifer C. Lai (ORCID: https://orcid.org/0000-0003-2092-6380)
- Mahesh Patel (ORCID: https://orcid.org/0000-0002-5128-4061)
- Nachiappan Chidambaram
- Benjamin Bruno
- Jonathan Ogle
Institutions
- University of Maryland, Baltimore (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- WinnMed (US)
- Intermountain Medical Center (US)
- Texas Dermatology and Laser Specialists (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Lipocine (United States) (US)
- Mayo Clinic in Florida (US)
- Dermatology Specialists (US)
- Methodist Dallas Medical Center (US)
- Saint Joseph's University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1097/hep.0000000000001146
- Citations
- 12
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 4.43