Auditory hallucinations as a presenting feature of LGi-1 encephalitis

<h3></h3> Leucine-rich glioma-inactivated 1 (LGI1) encephalitis is an autoantibody mediated limbic encephalitis. The clinical features of LGI1 encephalitis are well described and patients typically present with a variable combination of seizures, cognitive disorders, behavioural changes, and hyponatraemia.<sup>1</sup> In addition to the typical features of LGI1 encephalitis, both visual and auditory hallucinations have also been well documented.<sup>2</sup> However, reports of olfactory hallucinations, in LGI1 encephalitis specifically, are much more limited. We present a case of a 60-year-old man who was referred to the neurology clinic with olfactory hallucinations who was subsequently diagnosed with LGI1 encephalitis. <h3>References</h3> Li W, Wu S, Meng Q, <i>et al.</i> Clinical characteristics and short-term prognosis of LGI1 antibody encephalitis: a retrospective case study. <i>BMC Neurol</i>. 2018;<b>18</b>:96. Wang M, Cao X, Liu Q, Ma W, Guo X, Liu X. Clinical features of limbic encephalitis with LGI1 antibody. <i>Neuropsychiatr Dis Treat</i>. 2017;<b>13</b>:1589–1596.

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Published
2024-11-01
DOI
https://doi.org/10.1136/jnnp-2024-abn.84
Primary Topic
Autoimmune Neurological Disorders and Treatments
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article

Auditory hallucinations as a presenting feature of LGi-1 encephalitis

Friedrich Peter, P Hile Joseph, Knight Kathryn
Autoimmune Neurological Disorders and Treatments
article

Auditory hallucinations as a presenting feature of LGi-1 encephalitis

Friedrich Peter, P Hile Joseph, Knight Kathryn
article en

Abstract

<h3></h3> Leucine-rich glioma-inactivated 1 (LGI1) encephalitis is an autoantibody mediated limbic encephalitis. The clinical features of LGI1 encephalitis are well described and patients typically present with a variable combination of seizures, cognitive disorders, behavioural changes, and hyponatraemia.<sup>1</sup> In addition to the typical features of LGI1 encephalitis, both visual and auditory hallucinations have also been well documented.<sup>2</sup> However, reports of olfactory hallucinations, in LGI1 encephalitis specifically, are much more limited. We present a case of a 60-year-old man who was referred to the neurology clinic with olfactory hallucinations who was subsequently diagnosed with LGI1 encephalitis. <h3>References</h3> Li W, Wu S, Meng Q, <i>et al.</i> Clinical characteristics and short-term prognosis of LGI1 antibody encephalitis: a retrospective case study. <i>BMC Neurol</i>. 2018;<b>18</b>:96. Wang M, Cao X, Liu Q, Ma W, Guo X, Liu X. Clinical features of limbic encephalitis with LGI1 antibody. <i>Neuropsychiatr Dis Treat</i>. 2017;<b>13</b>:1589–1596.

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Auditory hallucinations as a presenting feature of LGi-1 encephalitis — Friedrich Peter, P Hile Joseph, et al. · (2024) | TGRS Research Map | TGRS