Disability in migraine: multicountry results from the CaMEO-International study

<h3>Background</h3> Although individual studies evaluating headache burden are available, few studies have been conducted across multiple countries using the same methodology. <h3>Design/Methods</h3> Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) was a global cross-sectional, web-based survey conducted in 2021-2022 This analysis evaluated migraine burden using the Migraine-Specific Quality of Life Questionnaire (MSQ) and the Work Productivity and Activity Impairment Questionnaire (WPAI). <h3>Results</h3> 14,492 participants respondents with migraine were included. Mean (SD) MSQ scores ranged from 57.7 (23.4) in Canada to 63.3 (21.1) in France for the role function restrictive domain, 67.6 (22.9) in Germany to 77.3 (22.7) in Japan for the role function preventive domain, and 63.9 (29.1) in the US to 69.2 (24.8) in France for the emotional function domain. Regarding WPAI, the mean (SD) percentage of work missed ranged from 4.3% (16.2) in France to 9.0% (21.7) in Germany, work impaired ranged from 31.2% (28.0) in France to 47.8% (28.6) in Japan, overall work impaired ranged from 33.5% (30.3) in France to 49.4% (29.4) in Japan, and activity impaired ranged from 39.3% (30.2) in France to 50.7% (28.4) in Japan. <h3>Conclusions</h3> Migraine is associated with substantial burden, including poor quality of life and work/activity impairment.