Boron-Mediated Selective C–H Hydroxylation of 1-Phenyl-1<i>H</i>-Pyrazoles
A novel strategy for boron-mediated C-H hydroxylation of 1-phenyl-1<i>H</i>-pyrazoles is presented. The protocol exhibits high efficiency and site exclusivity, offering the corresponding phenols in moderate to excellent yields with wide functional group tolerance under simple and metal-free conditions. Moreover, the hydroxylated products show good derivatization applications. This route provides a convenient and practical way to obtain functionalized 1-phenyl-1<i>H</i>-pyrazoles.
Authors
- Jiuzhong Huang (ORCID: https://orcid.org/0000-0002-6474-7707)
- Gaorong Wu (ORCID: https://orcid.org/0000-0002-6558-0662)
- Weiming Chen (ORCID: https://orcid.org/0000-0001-9496-7439)
- Xiangzhao Chen
- Yu-xi Liu (ORCID: https://orcid.org/0000-0002-3961-2691)
- Hao Huang (ORCID: https://orcid.org/0000-0001-5174-0920)
- Qingrong Wu
Institutions
- Ganzhou People's Hospital (CN)
- Gannan Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1021/acs.joc.4c02105
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Gannan Medical University