Accumulation of polyunsaturated lipids fuels ferroptosis to promote liver failure after extended hepatectomy in mice
Ferroptosis partly mediates the eHx-induced hepatocyte injury during the development of PHLF. Accumulation of polyunsaturated lipids in hepatocytes may promote eHx-induced ferroptosis, and targeting lipid peroxidation is a potential therapeutic strategy for PHLF.
Authors
- Hanbiao Liang
- Yisi Chen (ORCID: https://orcid.org/0000-0002-8045-3231)
- X. H. Mo (ORCID: https://orcid.org/0000-0001-6739-3839)
- Yonghong Peng (ORCID: https://orcid.org/0000-0002-5508-1819)
- Baoxiong Zhuang
- Leyi Liao
- Cuiting Liu (ORCID: https://orcid.org/0000-0002-6893-0787)
- Lei Yang (ORCID: https://orcid.org/0000-0002-5495-6556)
- Can Huang
- Jian Gan (ORCID: https://orcid.org/0000-0003-2645-6076)
- Chen Xie (ORCID: https://orcid.org/0000-0002-9058-8228)
- Kai Wang (ORCID: https://orcid.org/0000-0001-9705-6366)
- Biao Wang (ORCID: https://orcid.org/0000-0001-7691-4368)
- Qingping Li (ORCID: https://orcid.org/0000-0001-7526-2425)
- Minghui Zeng (ORCID: https://orcid.org/0000-0002-6055-6495)
- Chuanjiang Li (ORCID: https://orcid.org/0000-0002-3583-2881)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-0376-0622)
- Tianzhou Peng
- Xianqiu Wu
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Free Radical Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1080/10715762.2024.2423691
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province