Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats
HDAC upregulation might induce nociception through GAD65 and GABA inhibition in CCI-induced neuropathy. These findings strongly suggest that HDACs negatively regulate inhibitory neurotransmitters, constituting a potential therapeutic strategy for an epigenetic approach to manage NP.
Authors
- Zhi‐Hong Wen (ORCID: https://orcid.org/0000-0003-4411-044X)
- Hsiao‐Mei Kuo (ORCID: https://orcid.org/0000-0001-5749-7757)
- Pei‐Yu Chen (ORCID: https://orcid.org/0000-0003-2793-2361)
- Chien‐Wei Feng (ORCID: https://orcid.org/0000-0002-5586-4119)
- Zhi‐Kang Yao (ORCID: https://orcid.org/0000-0003-4791-6078)
- Hao‐Jung Cheng (ORCID: https://orcid.org/0000-0003-2301-7086)
- Nan-Fu Chen (ORCID: https://orcid.org/0000-0001-7262-1541)
- Chun‐Sung Sung
- Wu‐Fu Chen
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Kaohsiung Armed Forces General Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
Publication Details
- Journal
- PAIN Reports
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1097/pr9.0000000000001209
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Kaohsiung Armed Forces General Hospital
- National Science and Technology Council