Impact of Point-of-Care Birth Test-and-Treat on Clinical Outcomes Among Infants With HIV: A Cluster-Randomized Trial in Mozambique and Tanzania
PoC test-and-treat at birth is feasible in resource-poor settings and resulted in clinically relevant reduction of early mortality, though improved clinical outcomes were not sustained to month 18. Poor viral suppression may undermine early benefits, calling for better pediatric treatments and adherence interventions. Clinical Trials Registration. NCT04032522.
Authors
- Falume Chale (ORCID: https://orcid.org/0009-0000-2772-8008)
- Nédio Jonas Mabunda (ORCID: https://orcid.org/0000-0002-1848-4627)
- Michael J. Haule
- Chacha Mangu (ORCID: https://orcid.org/0009-0006-7631-6812)
- W Chris Buck (ORCID: https://orcid.org/0000-0002-6304-2262)
- Adolfo Vúbil (ORCID: https://orcid.org/0000-0002-1948-037X)
- Amina de Sousa
- Arne Kroidl (ORCID: https://orcid.org/0000-0003-3569-9176)
- Cornelia Lueer
- Willyhelmina Olomi (ORCID: https://orcid.org/0000-0003-2507-6805)
- Joaquim Lequechane
- Nuno Taveira (ORCID: https://orcid.org/0000-0003-0176-5585)
- Ana Duajá
- F. Rieß (ORCID: https://orcid.org/0000-0002-9976-4494)
- Mariana Mueller
- Timothy Bollinger
- Doreen Pamba (ORCID: https://orcid.org/0000-0002-6822-5682)
- Theodora Mbunda
- Ilesh Vinodrai Jani (ORCID: https://orcid.org/0000-0002-6880-6655)
- Nália Ismael (ORCID: https://orcid.org/0000-0003-1793-9471)
- Abhishek Bakuli (ORCID: https://orcid.org/0000-0001-5123-1974)
- Michael Höelscher (ORCID: https://orcid.org/0000-0002-7642-1835)
- Elmar Saathoff (ORCID: https://orcid.org/0000-0003-4874-380X)
- Kira Elsbernd (ORCID: https://orcid.org/0000-0003-1616-0212)
- Arlete Mahumane
- Fidelina Cumbe Zekoll
- Lilian Njovu
- Anange Lwilla (ORCID: https://orcid.org/0000-0002-8011-6948)
- Rute Marcelino (ORCID: https://orcid.org/0000-0002-4535-9725)
- Abisai Kisinda
- Issa Sabi (ORCID: https://orcid.org/0000-0002-1777-6572)
- Hellen Mahiga
- Nyanda Elias Ntinginya (ORCID: https://orcid.org/0000-0002-1575-4521)
- Bindiya Meggi (ORCID: https://orcid.org/0000-0002-4321-8478)
- Otto Geisenberger
- Chishamiso Mudenyanga (ORCID: https://orcid.org/0000-0002-6945-6693)
- Martina Rauscher (ORCID: https://orcid.org/0000-0002-9908-8852)
- Nhamo Chiwerengo
- Jorge E. Morais
- Raphael Edom
- Kassia Pereira (ORCID: https://orcid.org/0000-0003-4379-2805)
- João Luís Manuel
- J. B. Stephen
- Lara Samuel
- Daniel Machavae
- Siriel Boniface
- Lise Ellyin
- Araújo Patricio
- Dadirai Mutsaka
- Sergey Bocharnikov
- Wilson Simbine
- Absalão Zumba
- Jacinto Adolfo Ndarissone
- Maria Maviga
- Fatima Mecupa
- Festina Paschal
- Oliver Lyoba
Institutions
- University of California, Los Angeles (US)
- Zimmer Biomet (Netherlands) (NL)
- University of California System (US)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Mbeya University of Science and Technology (TZ)
- Escola Superior de Saúde Egas Moniz (PT)
- Clinton Health Access Initiative (US)
- Zimmer Biomet (Germany) (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- German Center for Infection Research (DE)
- Instituto Nacional de Saúde (MZ)
- National Institute for Medical Research (TZ)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1093/cid/ciae530
- Citations
- 4
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- World Health Organization
- University of Cape Town
- Muhimbili University of Health and Allied Sciences
- University of Health and Allied Sciences