Csp <sup>3</sup> –Csp <sup>2</sup> Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process
Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp<sup>3</sup>-Csp<sup>2</sup> bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.
Authors
- R. Martín Romero (ORCID: https://orcid.org/0000-0003-3218-8661)
- Chiara Portolani (ORCID: https://orcid.org/0000-0003-1629-2346)
- Mariola Tortosa (ORCID: https://orcid.org/0000-0002-5107-0549)
- María Martín (ORCID: https://orcid.org/0000-0003-3453-2235)
Institutions
- ORFEO-CINQA Research Network (ES)
- Universidad Autónoma de Madrid (ES)
- University of Bologna (IT)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1021/acscatal.4c06269
- Citations
- 12
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- H2020 European Research Council