Mineralocorticoid Receptor in Endothelial Cells Contributes to Vascular Endothelial Growth Factor Receptor Inhibitor-Induced Vascular and Kidney Damage
These results reveal that the MR, specifically in EC but not in SMCs, is necessary for VEGFRi-induced renal and vascular injury. While ineffective at lowering SBP, these data suggest potential therapeutic benefits of MR antagonists, like spironolactone, to protect the vasculature and the kidneys from VEGFRi-induced injury.
Authors
- Iris Zamir Jaffe (ORCID: https://orcid.org/0000-0001-9300-1253)
- Jaime Ibarrola (ORCID: https://orcid.org/0000-0003-0604-9289)
- Qing Lu
- Nicholas D. Camarda (ORCID: https://orcid.org/0000-0002-1853-0056)
- Rui Liu (ORCID: https://orcid.org/0000-0001-8757-3159)
- Angelina Tesfu
Institutions
- Tufts University (US)
- Tufts Medical Center (US)
Publication Details
- Journal
- American Journal of Hypertension
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1093/ajh/hpae140
- Citations
- 3
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Heart, Lung, and Blood Institute