In Silico Modeling and Validation of the Effect of Calcium-Activated Potassium Current on Ventricular Repolarization in Failing Myocytes
Our results highlight the importance of considering the SK channels to improve the characterization of HF-induced ventricular remodeling. Simulations across various single-cell and 1-D scenarios suggest that pharmacological SK channel inhibition could lead to adverse effects in failing ventricles.
Authors
- Jesús Carro (ORCID: https://orcid.org/0000-0001-7789-2973)
- Alba Pérez
- Esther Pueyo (ORCID: https://orcid.org/0000-0002-1960-407X)
- Violeta Monasterio (ORCID: https://orcid.org/0000-0001-5343-5671)
- Aída Oliván
- Marta Gómez-Gómez (ORCID: https://orcid.org/0000-0003-1532-000X)
Institutions
- Universidad de Zaragoza (ES)
- Universidad San Jorge (ES)
Publication Details
- Journal
- IEEE Journal of Biomedical and Health Informatics
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1109/jbhi.2024.3495027
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- European Regional Development Fund
- Agencia Estatal de Investigación