Organophosphorus Flame Retardants and Metabolic Disruption: An <i>in Silico</i> , <i>in Vitro</i> , and <i>in Vivo</i> Study Focusing on Adiponectin Receptors
<i>In silico</i>, <i>in vitro</i>, and <i>in vivo</i> assays suggest that aryl-OPFRs act as noncompetitive inhibitors of AdipoRs, preventing their activation by adiponectin, and thus function as antagonists to these receptors. Our study describes a novel MIE for chemical-induced metabolic disturbances and highlights a new pathway for environmental impact on metabolic health. https://doi.org/10.1289/EHP14634.
Authors
- Xiaochun Ma (ORCID: https://orcid.org/0000-0003-1055-4691)
- Cui Wang (ORCID: https://orcid.org/0000-0003-0276-2538)
- Mengting Xu (ORCID: https://orcid.org/0000-0002-6751-1986)
- Jiafan Feng
- Yifei Le (ORCID: https://orcid.org/0000-0002-4164-4983)
- Ying Liu (ORCID: https://orcid.org/0000-0002-6419-1980)
- Wanyue Wang (ORCID: https://orcid.org/0000-0003-3900-5100)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1289/ehp14634
- Citations
- 10
- Primary Topic
- Pesticide Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 6.00
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University