Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
This study found elevated GFAP levels in bvFTD compared to a large cohort of PPD, but NfL levels exhibited better performance in this distinction. These findings extend the literature on GFAP in bvFTD and build evidence for plasma NfL as a useful biomarker to assist with distinguishing bvFTD from PPD. Utilisation of NfL may improve timely and accurate diagnosis of bvFTD.
Authors
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- David Darby
- Christos Pantelis (ORCID: https://orcid.org/0000-0002-9565-0238)
- Naveen Thomas (ORCID: https://orcid.org/0000-0001-6876-1015)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Claudia Cicognola (ORCID: https://orcid.org/0000-0003-1806-7089)
- Olivia Dean (ORCID: https://orcid.org/0000-0002-2776-3935)
- Amy G. Brodtmann (ORCID: https://orcid.org/0000-0001-9466-2862)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Ian Everall (ORCID: https://orcid.org/0000-0003-3957-3861)
- Christa Dang (ORCID: https://orcid.org/0000-0003-0905-282X)
- Matthew Kang (ORCID: https://orcid.org/0000-0001-9375-3762)
- Dhamidhu Eratne (ORCID: https://orcid.org/0000-0002-3226-7645)
- Dennis Velakoulis (ORCID: https://orcid.org/0000-0002-8842-8479)
- Michael Berk (ORCID: https://orcid.org/0000-0002-5554-6946)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Suyi Ooi
- Shorena Janelidze (ORCID: https://orcid.org/0000-0003-2869-8378)
- Cassandra M. J. Wannan (ORCID: https://orcid.org/0000-0003-1317-4635)
- Alexander Santillo (ORCID: https://orcid.org/0000-0001-9717-0820)
- Chad Bousman (ORCID: https://orcid.org/0000-0001-6303-8696)
- Courtney Lewis (ORCID: https://orcid.org/0000-0002-8902-445X)
Institutions
- The Royal Melbourne Hospital (AU)
- Box Hill Hospital (AU)
- Deakin University (AU)
- The University of Melbourne (AU)
- University of Calgary (CA)
- King's College London (GB)
- Lund University (SE)
- Florey Institute of Neuroscience and Mental Health (AU)
- National Ageing Research Institute (AU)
- Orygen Youth Health (AU)
- Western Health (AU)
- Sunshine Hospital (AU)
- Molecular Research Institute (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of the Neurological Sciences
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1016/j.jns.2024.123291
- Citations
- 11
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.06