Mapping the gut microbial structural variations in healthy aging within the Chinese population
Mapping gut microbial structural variants (SVs) during human aging may provide fundamental knowledge and mechanistic understanding of the gut microbiome's relationship with healthy aging. We characterize gut microbial SVs from 3,230 Chinese participants, identifying key SVs associated with aging, healthy aging, and age-related chronic diseases. Our findings reveal a pattern of copy number loss in aging-related SVs, with 35 core SVs consistently detected. Additionally, eight SVs distinguish healthy from unhealthy aging, regardless of age. Notably, a 3-kbp deletion SV of Bifidobacterium pseudocatenulatum, encoding plant polysaccharide degradation, is regulated by plant-based diet and contributes to healthy aging through bile acid metabolism. Our analysis also connects SVs to age-related diseases, such as chronic kidney disease, via genes in the methionine-homocysteine pathway. This study deepens our understanding of the gut microbiome's role in aging and could inform future efforts to enhance lifespan and healthspan.
Authors
- Yimin Zhu (ORCID: https://orcid.org/0000-0002-7569-2158)
- Luqi Shen (ORCID: https://orcid.org/0009-0003-4349-4063)
- Yuanqing Fu (ORCID: https://orcid.org/0000-0002-3955-9376)
- Zengliang Jiang (ORCID: https://orcid.org/0000-0001-8062-8962)
- Ju‐Sheng Zheng (ORCID: https://orcid.org/0000-0001-6560-4890)
- Jun Tang (ORCID: https://orcid.org/0000-0002-6908-1027)
- Fengzhe Xu (ORCID: https://orcid.org/0000-0002-2686-1445)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-0661-7517)
- Yu‐Ming Chen (ORCID: https://orcid.org/0000-0003-1658-5528)
- Dan Zhou (ORCID: https://orcid.org/0000-0002-5313-8164)
- Zhaoping Wang
- Yue Xi (ORCID: https://orcid.org/0000-0003-1265-6624)
- Wanglong Gou (ORCID: https://orcid.org/0000-0002-4256-9452)
- Hui Zhao
- Kui Deng
- Wei Hu (ORCID: https://orcid.org/0000-0002-3309-4248)
Institutions
- Sun Yat-sen University (CN)
- Westlake University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
- Zhejiang University (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.celrep.2024.114968
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.70