Variability of Loa loa microfilarial counts in successive blood smears and its potential implication in drug-related serious adverse events
We observed a trend towards an increase in MFD<sub>2</sub> with an important variability between samples that may impact loiasis treatment allocation. We suggest that systematically sampling at least two successive TBSs might allow better MFD assessments to prevent post-treatment SAEs. Further studies are needed to verify this variability in larger samples as well as confirm the potential explanatory variables identified.
Authors
- Jérémy T. Campillo (ORCID: https://orcid.org/0000-0002-4400-5204)
- François Missamou (ORCID: https://orcid.org/0000-0002-6388-0266)
- Frédéric Louya
- Paul Bikita
- Marlhand C. Hemilembolo
- Cédric B. Chesnais (ORCID: https://orcid.org/0000-0002-8779-977X)
- Michel Boussinesq (ORCID: https://orcid.org/0000-0001-6312-0681)
- Sébastien D. S. Pion (ORCID: https://orcid.org/0000-0002-9468-7020)
- Tristan M. Lepage
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Ministère De La Santé (BF)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s13071-024-06494-0
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche