Synergistic effects of MK-1775 and gemcitabine on cytotoxicity in non-small cell lung cancer
MK-1775 enhances the cytotoxic effects of gemcitabine and pemetrexed in NSCLC cell lines and effectively inhibits tumor growth <i>in vivo</i>. These findings suggest that Wee1 inhibition by MK-1775, combined with chemotherapy, represents a promising therapeutic strategy for NSCLC treatment.
Authors
- Yu‐Tien Hsiao
- Wen‐Kuan Huang (ORCID: https://orcid.org/0000-0001-7789-8347)
- Ping‐Chih Hsu (ORCID: https://orcid.org/0000-0003-0173-7509)
- Chih-Hong Lo (ORCID: https://orcid.org/0000-0002-9417-7565)
- Tsai‐Hsien Hung (ORCID: https://orcid.org/0000-0002-6173-0862)
- Chiao‐Ping Chen (ORCID: https://orcid.org/0000-0002-6021-1083)
- Yi‐Ru Pan (ORCID: https://orcid.org/0000-0001-5812-2674)
- Chiao‐En Wu (ORCID: https://orcid.org/0000-0002-1081-8805)
- Chun‐Nan Yeh (ORCID: https://orcid.org/0000-0003-1455-092X)
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Taipei Municipal YangMing Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Heliyon
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e40299
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital, Linkou
- National Science and Technology Council