Predictive biomarkers for severity of respiratory syndrome: the role of eGFR and hematological parameters in ICU patients

Introduction: Studying respiratory syndromes like COVID-19 is crucial for understanding viral-induced inflammatory responses and their impact on organ function. Insights from these studies are essential for managing current and future pandemics and improving patient outcomes in respiratory health crises. This study investigates the behavior of the estimated glomerular filtration rate (eGFR) and its correlation with hematological parameters in ICU patients with COVID-19. Objective: To assess eGFR behavior and its correlation with hematological parameters in respiratory syndromes ICU patients. Materials and Methods: 217 patient records were analyzed, with 144 discharged and 73 deaths. Patients were divided into discharge and death groups and laboratory parameters such as glomerular filtration rate and blood count were.evaluated at admission and outcome. Results and Discussion: There was a significant reduction in eGFR among patients in the death group at both admission and outcome. Significant correlations were observed between eGFR and hemoglobin (Hb), total neutrophils (N), and platelets (PLT) at the outcome. These findings suggest that the reduction in eGFR is a predictor of poor prognosis in COVID-19 ICU patients. Additionally, the significant correlations between eGFR and hematological parameters highlight their role in the inflammatory process and clinical deterioration. Conclusion: The reduction of eGFR is a significant predictor of poor prognosis in ICU patients with COVID-19. Significant correlations between eGFR and hematological parameters underscore their importance in the inflammatory process and disease progression. Studying respiratory syndromes like COVID-19 is crucial for understanding viral-induced inflammatory responses and improving critical care strategies for future respiratory health crises.