Bio-fabrication of biologically active copper nanocomposite

Green routes for nucleation of nanostructures are recently applied for the biomedical applications, due to their affinity and feasibility. For instance, copper nanostructures are applicable for inhibition of microbial infections and ulcers. Hereby, this work is aimed at investigation for the possible contribution of Sidr honey (SH) in the formation of copper based-nanocomposites (Cu@SH). The overall results affirmed that, under the optimal experimental conditions, spherical shaped Cu@SH nanocomposites with quite small particle size of 16.2-30.1 nm were successfully clustered. The bio-fabricated Cu@SH nanocomposites showed superior antimicrobial action against all of the examined strains, whereas, the most potent inhibition was obtained against <i>St. aureus</i> (11 mm), <i>E. Coli</i> (17 mm) & <i>C. albicans</i> (14 mm). The nanocomposite that was prepared with higher concentration of copper precursor is exhibited with the highest percentage of cancer cell inhibition (77 %) and highest anti-inflammation action (NO percentage 89 %). In summarization, Cu@SH nanocomposites showed high affinity to be concurrently applicable as therapeutic drugs for the microbial infectious, cancer and inflammation diseases.