Synthesis of Amide-Containing Indolo[2,1-<i>a</i>]isoquinoline Derivatives via Palladium-Catalyzed Cascade Reactions
A convenient palladium-catalyzed cascade cyclization reaction for the construction of amide-containing indolo[2,1-<i>a</i>]isoquinolines from 2-aryl-<i>N</i>-propenyl indoles with aromatic amines and chloroform is described. A variety of amide-containing indolo[2,1-<i>a</i>]isoquinoline compounds have been successfully synthesized in moderate to good yields in which chloroform is employed as the source of CO.
Authors
- Leming Wang (ORCID: https://orcid.org/0000-0002-1968-7557)
- Jianyi Ma (ORCID: https://orcid.org/0000-0001-8774-582X)
- Shufeng Chen (ORCID: https://orcid.org/0000-0002-7021-2581)
Institutions
- Inner Mongolia University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1021/acs.joc.4c02069
- Citations
- 3
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China