Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
Thyroid vascularization and hemodynamics become altered in thyroid pathologies and could thus inform diagnostics, therapy planning, and follow-up. However, the current non-invasive monitoring methods available in clinics lack the necessary sensitivity and/or are impractical for large-scale deployment. As a step towards proposing a new modality, we applied the first platform, to our knowledge, designed to do simultaneous measurements of neck anatomy and thyroid microvascular hemodynamics and metabolism in a single probe placement, integrating state-of-the-art near-infrared spectroscopy techniques and clinical ultrasound. A rich dataset was formed with sixty-five subjects (forty-eight females), including eighteen healthy volunteers and forty-seven patients with thyroid nodules, characterizing thyroid tissue and the effects of demographic and anatomical variables while preserving the standard clinical workflow. We have found marked reductions with age and body mass index in thyroid total hemoglobin concentration (<i>THC</i>), tissue oxygen saturation (<i>StO</i> <sub>2</sub>), and blood flow index (<i>BFi</i>), among others. Patients showed lower <i>THC</i> and <i>BFi</i> than healthy subjects, and the limited sample of malignant nodules showed a higher <i>StO</i> <sub>2</sub> than the benign. These findings support the need for personalized clinical approaches.
Authors
- Mauro Buttafava (ORCID: https://orcid.org/0000-0002-5446-8026)
- Udo M. Weigel
- Lorenzo Cortese (ORCID: https://orcid.org/0000-0001-9258-0863)
- Sabina Ruiz Janer
- Marco Renna (ORCID: https://orcid.org/0000-0002-8143-5131)
- Giuseppe Lo Presti (ORCID: https://orcid.org/0000-0003-1308-6619)
- Hamid Dehghani (ORCID: https://orcid.org/0000-0003-4117-0412)
- Turgut Durduran (ORCID: https://orcid.org/0000-0001-5838-1027)
- Laura Di Sieno (ORCID: https://orcid.org/0000-0002-3028-3705)
- Gloria Aranda Velazquez
- Bogdan Rosinski
- Alberto Tosi (ORCID: https://orcid.org/0000-0003-1210-2875)
- Stanisław Wojtkiewicz (ORCID: https://orcid.org/0000-0002-5556-4730)
- Mattia Squarcia
- Sixte de Fraguier
- Mireia Mora (ORCID: https://orcid.org/0000-0002-5887-5016)
- Davide Contini (ORCID: https://orcid.org/0000-0003-1209-9397)
- Alberto Dalla Mora (ORCID: https://orcid.org/0000-0002-2783-6217)
- Marta Zanoletti (ORCID: https://orcid.org/0000-0003-4724-7273)
- Felicia A. Hanzu (ORCID: https://orcid.org/0000-0002-2399-4023)
- Pablo Fernández (ORCID: https://orcid.org/0000-0003-0880-0910)
- An Nguyen‐Dinh
- Dibya J. Sarangi
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Harvard University (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Institute of Photonic Sciences (ES)
- Universidad Nacional del Centro de la Provincia de Buenos Aires (AR)
- SdPhotonics (United States) (US)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Kairos Future (Sweden) (SE)
- Vermon (France) (FR)
- Hospital Clínic de Barcelona (ES)
- Institute of Biocybernetics and Biomedical Engineering (PL)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University of Birmingham (GB)
- Politecnico di Milano (IT)
Publication Details
- Journal
- Biomedical Optics Express
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1364/boe.538141
- Citations
- 1
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Fundación Cellex
- Centres de Recerca de Catalunya
- Fundación Carmen y Severo Ochoa
- European Commission
- Institució Catalana de Recerca i Estudis Avançats
- FUNDACIÓ Privada MIR-PUIG
- Horizon 2020 Framework Programme
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- European Regional Development Fund
- Agencia Estatal de Investigación
- Departament d'Empresa i Coneixement, Generalitat de Catalunya
- European Social Fund